Sepsis is a life-threatening yet common disease, still posing high mortality worldwide.Sepsis-related deaths primarily occur during immunosuppression; the disease can hamper the numbers Puzzles and function of B cells, which mediate innate and adaptive immune responses to maintain immune homeostasis.Dysfunction of B cells, along with aggravated imm

Zika virus (ZIKV), a mosquito-transmitted Flavivirus, emerged in the last decade causing serious diseases and affecting human health globally.Currently, no licensed vaccines or antivirals are available to combat ZIKV, although several vaccine candidates are in the pipeline.In recent years, the presence of non-canonical G-quadruplex (GQ) secondary s

Secretory cells in glands and the nervous system frequently package and store proteins destined for regulated secretion in dense-core granules (DCGs), which disperse when released from the cell surface.Despite the relevance of this dynamic process to diseases such as diabetes and human neurodegenerative disorders, our mechanistic understanding is r